New York City is thrown into chaos by the assaults of the Bone Collector, a serial kidnapper and killer who gives the police a chance to save his victims from death by leaving obscure clues. The cops go to Lincoln Rhyme, an ex-NYPD forensics expert left paralysed after an accident on the job. Rhyme reluctantly postpones his ambitions towards suicide and puts together a forensic investigation team, enlisting as his eyes and ears young police officer Amelia Sachs.

Rhyme digs deep into the only world he has left - his astonishing mind - and slowly begins to narrow the noose around the Bone Collector. But the kidnapper is narrowing his own noose - around Lincoln Rhyme.